A research team led by Professor NG Wai Lung Billy, Assistant Professor in the School of Pharmacy and an investigator at the CUHK Li Ka Shing Institute of Health Sciences, has developed a novel class of small molecules called O-GlcNAcylation Targeting Chimeras (OGTACs). This pioneering method allows for precise manipulation of protein function in living cells and has the potential to revolutionise the treatment of various chronic diseases. The study has been published in the prestigious Journal of the American Chemical Society.

For more detailed information, please refer to the following link:

CUHK discovers groundbreaking method for precise regulation of human proteins Paving the way for the development of new drugs for numerous diseases

The link for the full study:
https://pubs.acs.org/doi/epdf/10.1021/jacs.3c14380